Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T68777 Target Info
Target Name Lysine N-methyltransferase 3B (NSD1)
Synonyms Nuclear receptor-binding SET domain-containing protein 1; NR-binding SET domain-containing protein; NR-binding SET domain containing protein; KMT3B; Hypothetical protein FLJ22263 similar to nuclear receptor-binding SET-domain protein 1; Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; H4-K20-HMTase; H3-K36-HMTase; Androgen receptor-associated protein of 267 kDa; Androgen receptor-associated coregulator 267; Androgen receptor coactivator 267 kDa protein; Androgen receptor associated coregulator 267; ARA267
Target Type Literature-reported Target
Gene Name NSD1
Biochemical Class Methyltransferase
UniProt ID
NSD1_HUMAN 
Target Interacting Proteins  Top
Histones [+] 1 Histones +
Interacting Protein Name Histone H4 (H4) Interacting Protein Interacting Protein Info
UniProt ID
H4_HUMAN 
Synonyms H4/p
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [1]
2 Co-crystal Structure [2]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [3]
2 Yeast two hybrid [4]
References  Top
REF 1 Substrate specificity analysis and novel substrates of the protein lysine methyltransferase NSD1. Chem Biol. 2014 Feb 20;21(2):226-37.
REF 2 Structural insights into the regulation and the recognition of histone marks by the SET domain of NSD1. Biochem Biophys Res Commun. 2011 Aug 26;412(2):214-9.
REF 3 Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells. J Biol Chem. 2001 Nov 2;276(44):40417-23.
REF 4 A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors. Nucleic Acids Res. 2013 Nov;41(21):9663-79.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.