Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T68877 Target Info
Target Name DNA-binding protein inhibitor ID-2 (ID2)
Synonyms bHLHb26; Inhibitor of differentiation 2; Inhibitor of DNA binding 2; Id2; Class B basic helix-loop-helix protein 26
Target Type Literature-reported Target
Gene Name ID2
UniProt ID
ID2_HUMAN 
Target Interacting Proteins  Top
Transcription regulators [+] 3 Transcription regulators +
Interacting Target Name Transcription factor E2-alpha (TCF3) Literature-reported Target Interacting Protein Info
UniProt ID
TFE2_HUMAN 
Synonyms Transcription factor ITF-1; Transcription factor 3; TCF-3; Kappa-E2-binding factor; ITF1; Immunoglobulin transcription factor 1; Immunoglobulin enhancer-binding factor E12/E47; E2A; Class B basic helix-loop-helix protein 21; bHLHb21
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Yeast two hybrid [4]
Interacting Protein Name Transcription factor 12 (TCF12) Interacting Protein Interacting Protein Info
UniProt ID
HTF4_HUMAN 
Synonyms CRS3; HEB; HTF4; HsT17266; bHLHb20
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Yeast two hybrid [4]
Interacting Protein Name Transcription factor 4 (TCF4) Interacting Protein Interacting Protein Info
UniProt ID
ITF2_HUMAN 
Synonyms E2.2; ITF.2; ITF2; PTHS; SEF.2; SEF2; SEF2.1; SEF2.1A; SEF2.1B; SEF2.1D; TCF.4; bHLHb19
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [4]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016 Jan 14;529(7585):172-7.
REF 3 Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5831-6.
REF 4 Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J Biol Chem. 1997 Aug 8;272(32):19785-93.

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