Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T69506 | Target Info | |||
| Target Name | Orphan nuclear receptor NR1I3 (NR1I3) | ||||
| Synonyms | Orphan nuclear receptor MB67; Orphan nuclear receptor CAR; Nuclear receptor subfamily 1 group I member 3; Nuclear receptor CAR; Constitutive androstane receptor; Constitutive active response; Constitutive activator of retinoid response; CAR | ||||
| Target Type | Successful Target | ||||
| Gene Name | NR1I3 | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Protein Name | Nuclear receptor coactivator 1 (NCOA1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-MS | [2] | |||
| 3 | Yeast two hybrid | [3] | |||
| Heat shock proteins | [+] 1 Heat shock proteins | + | |||
| Interacting Target Name | Heat shock protein 90 alpha (HSP90A) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Luminescence | [4] | |||
| 2 | Affinity Capture-Western | [5] | |||
| Nuclear hormone receptors | [+] 1 Nuclear hormone receptors | + | |||
| Interacting Target Name | Retinoic acid receptor RXR-alpha (RXRA) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Co-localization | [6] | |||
| 2 | Reconstituted Complex | [7] | |||
| 3 | Reconstituted Complex | [6] | |||
| 4 | Reconstituted Complex | [8] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 2 | The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440. | ||||
| REF 3 | Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13. | ||||
| REF 4 | Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001. | ||||
| REF 5 | Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. Biochem J. 2014 Feb 15;458(1):95-107. | ||||
| REF 6 | Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region. Biochem Pharmacol. 2010 Jan 15;79(2):261-9. | ||||
| REF 7 | Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol Pharmacol. 2002 Aug;62(2):359-65. | ||||
| REF 8 | Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators. J Biol Chem. 2005 Jul 15;280(28):26543-56. | ||||
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