Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T70027 | Target Info | |||
Target Name | Torsin-1A (TOR1A) | ||||
Synonyms | Torsin family 1 member A; Torsin ATPase-1A; TORA; TA; Dystonia 1 protein; DYT1; DQ2 | ||||
Target Type | Literature-reported Target | ||||
Gene Name | TOR1A | ||||
Biochemical Class | Acid anhydride hydrolase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
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Other proteins | [+] 3 Other proteins | + | |||
Interacting Protein Name | Torsin-1A-interacting protein 2 (TOR1AIP2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | IFRG15; LULL1; NET9 | ||||
Evidence Score (E-score) | 10 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-Western | [2] | |||
3 | Affinity Capture-Western | [1] | |||
4 | Affinity Capture-Western | [3] | |||
5 | Affinity Capture-Western | [4] | |||
6 | Affinity Capture-Western | [5] | |||
7 | Co-crystal Structure | [6] | |||
8 | Co-purification | [5] | |||
9 | Reconstituted Complex | [5] | |||
10 | Reconstituted Complex | [6] | |||
Interacting Protein Name | Torsin-1A-interacting protein 1 (TOR1AIP1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | LAP1; LAP1B | ||||
Evidence Score (E-score) | 6 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [2] | |||
2 | Affinity Capture-Western | [1] | |||
3 | Affinity Capture-Western | [3] | |||
4 | Affinity Capture-Western | [5] | |||
5 | Co-purification | [5] | |||
6 | Reconstituted Complex | [5] | |||
Interacting Protein Name | Calnexin (CANX) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CNX; IP90; P90 | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [7] | |||
3 | Affinity Capture-Western | [3] |
References | Top | ||||
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REF 1 | Interaction of torsinA with its major binding partners is impaired by the dystonia-associated DeltaGAG deletion. J Biol Chem. 2009 Oct 9;284(41):27866-74. | ||||
REF 2 | A unique redox-sensing sensor II motif in TorsinA plays a critical role in nucleotide and partner binding. J Biol Chem. 2010 Nov 26;285(48):37271-80. | ||||
REF 3 | Regulation of Torsin ATPases by LAP1 and LULL1. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1545-54. | ||||
REF 4 | LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation. Mol Biol Cell. 2009 Jun;20(11):2661-72. | ||||
REF 5 | The mechanism of Torsin ATPase activation. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4822-31. | ||||
REF 6 | Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia. Elife. 2016 Aug 4;5. pii: e17983. | ||||
REF 7 | The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440. |
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