Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T70027 Target Info
Target Name Torsin-1A (TOR1A)
Synonyms Torsin family 1 member A; Torsin ATPase-1A; TORA; TA; Dystonia 1 protein; DYT1; DQ2
Target Type Literature-reported Target
Gene Name TOR1A
Biochemical Class Acid anhydride hydrolase
UniProt ID
TOR1A_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 3 Other proteins +
Interacting Protein Name Torsin-1A-interacting protein 2 (TOR1AIP2) Interacting Protein Interacting Protein Info
UniProt ID
TOIP2_HUMAN 
Synonyms IFRG15; LULL1; NET9
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [1]
4 Affinity Capture-Western [3]
5 Affinity Capture-Western [4]
6 Affinity Capture-Western [5]
7 Co-crystal Structure [6]
8 Co-purification [5]
9 Reconstituted Complex [5]
10 Reconstituted Complex [6]
Interacting Protein Name Torsin-1A-interacting protein 1 (TOR1AIP1) Interacting Protein Interacting Protein Info
UniProt ID
TOIP1_HUMAN 
Synonyms LAP1; LAP1B
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [5]
5 Co-purification [5]
6 Reconstituted Complex [5]
Interacting Protein Name Calnexin (CANX) Interacting Protein Interacting Protein Info
UniProt ID
CALX_HUMAN 
Synonyms CNX; IP90; P90
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [7]
3 Affinity Capture-Western [3]
References  Top
REF 1 Interaction of torsinA with its major binding partners is impaired by the dystonia-associated DeltaGAG deletion. J Biol Chem. 2009 Oct 9;284(41):27866-74.
REF 2 A unique redox-sensing sensor II motif in TorsinA plays a critical role in nucleotide and partner binding. J Biol Chem. 2010 Nov 26;285(48):37271-80.
REF 3 Regulation of Torsin ATPases by LAP1 and LULL1. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1545-54.
REF 4 LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation. Mol Biol Cell. 2009 Jun;20(11):2661-72.
REF 5 The mechanism of Torsin ATPase activation. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4822-31.
REF 6 Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia. Elife. 2016 Aug 4;5. pii: e17983.
REF 7 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.

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