Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T71492 Target Info
Target Name PDZ domain containing-protein (PDZK1)
Synonyms Sodium-hydrogen exchanger regulatory factor 3; PDZD1; PDZ domain-containing protein 1; NaPi-Cap1; Na/Pi cotransporter C-terminal-associated protein 1; Na(+)/H(+) exchanger regulatory factor 3; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; NHERF3; NHERF-3; Multi-PDZ domain containing adaptor protein; CFTR-associated protein of 70 kDa; CAP70
Target Type Literature-reported Target
Gene Name PDZK1
UniProt ID
NHRF3_HUMAN 
Target Interacting Proteins  Top
Hydrolysis-driven transporters [+] 3 Hydrolysis-driven transporters +
Interacting Target Name cAMP-dependent chloride channel (CFTR) Successful Target Interacting Protein Info
UniProt ID
CFTR_HUMAN 
Synonyms Cystic fibrosis transmembrane conductance regulator; Channel conductancecontrolling ATPase; cAMP-dependent chloride channel; cAMPdependent chloride channel; ATP-binding cassette sub-family C member 7; ATPbinding cassette subfamily C member 7; ABCC7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [1]
Interacting Target Name Multidrug resistance-associated protein 2 (ABCC2) Literature-reported Target Interacting Protein Info
UniProt ID
MRP2_HUMAN 
Synonyms MRP2; CMRP; CMOAT1; CMOAT; Canalicular multispecific organic anion transporter 1; Canalicular multidrug resistance protein; ATP-binding cassette, sub-family C, member 2; ATP-binding cassette sub-family C member 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [3]
2 Yeast two hybrid [4]
Interacting Target Name Multidrug resistance protein 4 (ABCC4) Literature-reported Target Interacting Protein Info
UniProt ID
MRP4_HUMAN 
Synonyms Multispecific organic anion transporter B; Multidrug resistanceassociated protein 4; MRP/cMOATrelated ABC transporter; MOATB; ATPbinding cassette subfamily C member 4; ABCC4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Reconstituted Complex [6]
Putative transporters [+] 1 Putative transporters +
Interacting Target Name Scavenger receptor class B member 1 (SCARB1) Literature-reported Target Interacting Protein Info
UniProt ID
SCRB1_HUMAN 
Synonyms SR-BI; SRB1; Scavenger receptor class B type I; High-density lipoprotein receptor SR-BI; Collagen type I receptor, thrombospondin receptor-like 1; CLA-1; CLA1; CD36L1; CD36 antigen-like 1; CD36 and LIMPII analogous 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [7]
Other proteins [+] 1 Other proteins +
Interacting Protein Name PDZK1-interacting protein 1 (PDZK1IP1) Interacting Protein Interacting Protein Info
UniProt ID
PDZ1I_HUMAN 
Synonyms DD96; MAP17; SPAP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [8]
3 Reconstituted Complex [9]
4 Reconstituted Complex [10]
5 Yeast two hybrid [9]
References  Top
REF 1 The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins. J Biol Chem. 2003 Feb 21;278(8):6440-9.
REF 2 Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity. Cell. 2000 Sep 29;103(1):169-79.
REF 3 ATP-binding cassette transporter isoform C2 localizes to the apical plasma membrane via interactions with scaffolding protein. J Biochem. 2011 Feb;149(2):177-89.
REF 4 PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein. Lab Invest. 1999 Sep;79(9):1161-70.
REF 5 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 6 Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Cell. 2007 Nov 30;131(5):940-51.
REF 7 A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver. J Biol Chem. 2002 Sep 13;277(37):34042-7.
REF 8 Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. J Biol Chem. 2003 Aug 1;278(31):28528-32.
REF 9 PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. Kidney Int. 2003 Nov;64(5):1733-45.
REF 10 Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells. Am J Physiol Renal Physiol. 2003 Oct;285(4):F784-91.

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