Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T72252 Target Info
Target Name Caspase-7 (CASP7)
Synonyms MCH3; ICE-like apoptotic protease 3; ICE-LAP3; CMH-1; CASP-7; Apoptotic protease Mch-3
Target Type Clinical trial Target
Gene Name CASP7
Biochemical Class Peptidase
UniProt ID
CASP7_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 3 Acyltransferases +
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-crystal Structure [2]
3 Co-crystal Structure [3]
4 Reconstituted Complex [4]
5 Reconstituted Complex [5]
6 Reconstituted Complex [6]
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [8]
3 Reconstituted Complex [8]
Interacting Target Name Cellular inhibitor of apoptosis 2 (BIRC3) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC3_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 1; TNFR2TRAFsignaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; hIAP-1; hIAP1; C-IAP2; CIAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
Other proteins [+] 1 Other proteins +
Interacting Target Name Apoptosis inhibitor survivin (BIRC5) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC5_HUMAN 
Synonyms Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; API4
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [11]
2 Reconstituted Complex [12]
References  Top
REF 1 Expression of B-crystallin overrides the anti-apoptotic activity of XIAP. Neuro Oncol. 2012 Nov;14(11):1332-45.
REF 2 Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell. 2001 Mar 9;104(5):781-90.
REF 3 Structural basis of caspase-7 inhibition by XIAP. Cell. 2001 Mar 9;104(5):769-80.
REF 4 A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem. 1998 Apr 3;273(14):7787-90.
REF 5 X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 1997 Jul 17;388(6639):300-4.
REF 6 Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac. J Biol Chem. 2003 Dec 5;278(49):49517-22.
REF 7 IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Nat Cell Biol. 2005 Jan;7(1):70-7.
REF 8 The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J Biol Chem. 2009 May 8;284(19):12772-82.
REF 9 The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem. 2006 Feb 10;281(6):3254-60.
REF 10 The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 1997 Dec 1;16(23):6914-25.
REF 11 An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry. 2001 Jan 30;40(4):1117-23.
REF 12 IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998 Dec 1;58(23):5315-20.

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