Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T75210 | Target Info | |||
| Target Name | LDL receptor related protein-2 (LRP-2) | ||||
| Synonyms | Megalin; Lowdensity lipoprotein receptorrelated protein 2; Low-density lipoprotein receptor-related protein 2; Gp330; Glycoprotein 330 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | LRP2 | ||||
| Biochemical Class | Low density lipoprotein receptor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Microtubule-associated | [+] 1 Microtubule-associated | + | |||
| Interacting Target Name | Presynaptic density protein 95 (DLG4) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Synapse-associated protein 90; SAP-90; SAP90; PSD-95; PSD95; Postsynaptic density-95; Postsynaptic density protein 95; Disks large homolog 4; Discs, large homolog 4 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Reconstituted Complex | [2] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | PDZ domain-containing protein GIPC1 (GIPC1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | C19orf3; GIPC; GLUT1CBP; Hs.6454; IIP.1; NIP; RGS19IP1; SEMCAP; SYNECTIIN; SYNECTIN; TIP.2 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [3] | |||
| 2 | Yeast two hybrid | [2] | |||
| 3 | Yeast two hybrid | [4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins. Biochem J. 2003 Jul 15;373(Pt 2):381-91. | ||||
| REF 2 | Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem. 2000 Aug 18;275(33):25616-24. | ||||
| REF 3 | GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. J Am Soc Nephrol. 2002 Apr;13(4):918-27. | ||||
| REF 4 | Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. J Cell Sci. 2003 Feb 1;116(Pt 3):453-61. | ||||
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