| References |
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| REF 2 |
UBE2O negatively regulates TRAF6-mediated NF-B activation by inhibiting TRAF6 polyubiquitination. Cell Res. 2013 Mar;23(3):366-77.
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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001 Sep 6;413(6851):78-83.
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A Pseudomonas aeruginosaIR effector mediates immune evasion by targetingBAP1 and TLR adaptors. EMBO J. 2017 Jul 3;36(13):1869-1887.
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MAPPIT analysis of TLR adaptor complexes. FEBS Lett. 2007 Feb 20;581(4):629-36.
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Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site. J Cell Sci. 2010 Jan 15;123(Pt 2):256-65.
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Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase. J Biol Chem. 2000 Nov 3;275(44):34035-40.
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MAPPIT analysis of early Toll-like receptor signalling events. Immunol Lett. 2008 Mar 15;116(2):141-8.
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Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. J Immunol. 2003 Apr 1;170(7):3565-71.
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Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
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Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88. J Biol Chem. 2002 Jul 5;277(27):24169-79.
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A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. Mol Cell Biol. 2005 Aug;25(15):6521-32.
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IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5567-72.
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Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med. 2003 Jan 20;197(2):263-8.
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| REF 15 |
IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem. 1999 Jul 2;274(27):19403-10.
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Constitutive association of MyD88 to IRAK in HTLV-I-transformed T cells. Exp Hematol. 2007 Dec;35(12):1812-22.
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Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound. J Leukoc Biol. 2007 Oct;82(4):801-10.
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| REF 18 |
Bacterial lipoprotein-induced self-tolerance and cross-tolerance to LPS are associated with reduced IRAK-1 expression and MyD88-IRAK complex format... J Leukoc Biol. 2006 Apr;79(4):867-75.
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A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
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Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 2015 Apr 23;161(3):647-660.
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IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways. J Biol Chem. 2006 Apr 14;281(15):10073-80.
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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 2004 Oct;5(10):1061-8.
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| REF 23 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
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Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
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Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
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