Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T75643 Target Info
Target Name Pattern recognition receptor NOD2 (NOD2)
Synonyms Nucleotidebinding oligomerization domaincontaining protein 2; Nucleotide-binding oligomerization domain-containing protein 2; Inflammatory bowel disease protein 1; IBD1; Caspase recruitment domaincontaining protein 15; Caspase recruitment domain-containing protein 15; CARD15
Target Type Clinical trial Target
Gene Name NOD2
UniProt ID
NOD2_HUMAN 
Target Interacting Proteins  Top
Intermediate filaments [+] 1 Intermediate filaments +
Interacting Protein Name Vimentin (VIM) Interacting Protein Interacting Protein Info
UniProt ID
VIME_HUMAN 
Synonyms CTRCT30; HEL113
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Yeast two hybrid [1]
4 Yeast two hybrid [2]
Kinases [+] 2 Kinases +
Interacting Protein Name Receptor-interacting protein 2 (RIP2) Interacting Protein Interacting Protein Info
UniProt ID
RIPK2_HUMAN 
Synonyms UNQ277/PRO314/PRO34092; Tyrosine-protein kinase RIPK2; RIP-like-interacting CLARP kinase; RIP-2; RIP2; RICK; Receptor-interacting serine/threonine-protein kinase 2; Receptor-interacting protein 2; CARDIAK; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [7]
6 Affinity Capture-Western [8]
7 Affinity Capture-Western [9]
8 Affinity Capture-Western [10]
9 Affinity Capture-Western [2]
10 Fluorescence Resonance Energy Transfer [2]
11 Yeast two hybrid [2]
Interacting Target Name TGF-beta-activated kinase 1 (MAP3K7) Literature-reported Target Interacting Protein Info
UniProt ID
M3K7_HUMAN 
Synonyms Transforming growth factor-beta-activated kinase 1; TAK1; Mitogen-activated protein kinase kinase kinase 7
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Affinity Capture-Western [12]
3 Reconstituted Complex [12]
4 Reconstituted Complex [13]
References  Top
REF 1 TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease. Gastroenterology. 2011 Sep;141(3):972-981.e1-2.
REF 2 Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. PLoS One. 2016 Nov 3;11(11):e0165420.
REF 3 Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem. 2001 Feb 16;276(7):4812-8.
REF 4 ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways. Curr Biol. 2009 Aug 11;19(15):1255-63.
REF 5 The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr Biol. 2004 Dec 29;14(24):2217-27.
REF 6 Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses. Genes Dev. 2010 Dec 1;24(23):2666-77.
REF 7 The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell. 2012 Jun 29;46(6):746-58.
REF 8 A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses. J Biol Chem. 2011 Jan 21;286(3):1938-50.
REF 9 LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes. Cell Rep. 2015 Dec 15;13(10):2258-72.
REF 10 SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Cell Rep. 2016 Aug 30;16(9):2271-80.
REF 11 TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem. 2008 Jan 4;283(1):137-44.
REF 12 Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J Biol Chem. 2004 Jun 11;279(24):25876-82.
REF 13 Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem J. 2007 Jun 1;404(2):179-90.

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