Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T76414 Target Info
Target Name Glutamate receptor ionotropic NMDA 2B (NMDAR2B)
Synonyms NR3; NR2B; NMDA receptor subunit 2B; NMDA receptor NR2B; NMDA NR2B receptor; N-methylD-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; HNR3; Glutamate receptor ionotropic, NMDA 2B; Glutamate receptor NR2B subunit; Glutamate [NMDA] receptor subunit epsilon-2; GluN2B
Target Type Successful Target
Gene Name GRIN2B
Biochemical Class Glutamate-gated ion channel
UniProt ID
NMDE2_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Microtubule-associated [+] 3 Microtubule-associated +
References  Top
REF 1 Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. Am J Physiol Cell Physiol. 2002 Jun;282(6):C1396-403.
REF 2 Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci. 1996 Apr 1;16(7):2157-63.
REF 3 Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995 Sep 22;269(5231):1737-40.
REF 4 NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat Cell Biol. 2003 Jun;5(6):520-30.
REF 5 CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. Neuron. 1998 Apr;20(4):693-707.
REF 6 Binding of neuroligins to PSD-95. Science. 1997 Sep 5;277(5331):1511-5.

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