Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T76414 Target Info
Target Name Glutamate receptor ionotropic NMDA 2B (NMDAR2B)
Synonyms NR3; NR2B; NMDA receptor subunit 2B; NMDA receptor NR2B; NMDA NR2B receptor; N-methylD-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; HNR3; Glutamate receptor ionotropic, NMDA 2B; Glutamate receptor NR2B subunit; Glutamate [NMDA] receptor subunit epsilon-2; GluN2B
Target Type Successful Target
Gene Name GRIN2B
Biochemical Class Glutamate-gated ion channel
UniProt ID
NMDE2_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Disks large homolog 1 (DLG1) Interacting Protein Interacting Protein Info
UniProt ID
DLG1_HUMAN 
Synonyms DLGH1; SAP.97; SAP97; dJ1061C18.1.1; hdlg
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Yeast two hybrid [2]
Microtubule-associated [+] 3 Microtubule-associated +
Interacting Target Name Presynaptic density protein 95 (DLG4) Clinical trial Target Interacting Protein Info
UniProt ID
DLG4_HUMAN 
Synonyms Synapse-associated protein 90; SAP-90; SAP90; PSD-95; PSD95; Postsynaptic density-95; Postsynaptic density protein 95; Disks large homolog 4; Discs, large homolog 4
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [4]
4 Far Western [2]
5 Reconstituted Complex [3]
6 Reconstituted Complex [5]
7 Yeast two hybrid [6]
8 Yeast two hybrid [2]
Interacting Protein Name Disks large homolog 3 (DLG3) Interacting Protein Interacting Protein Info
UniProt ID
DLG3_HUMAN 
Synonyms MRX; MRX90; NEDLG; PPP1R82; SAP102; XLMR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [1]
3 Yeast two hybrid [6]
Interacting Protein Name Disks large homolog 2 (DLG2) Interacting Protein Interacting Protein Info
UniProt ID
DLG2_HUMAN 
Synonyms PPP1R58; PSD.93; PSD93; chapsyn.110
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Yeast two hybrid [6]
References  Top
REF 1 Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. Am J Physiol Cell Physiol. 2002 Jun;282(6):C1396-403.
REF 2 Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci. 1996 Apr 1;16(7):2157-63.
REF 3 Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995 Sep 22;269(5231):1737-40.
REF 4 NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat Cell Biol. 2003 Jun;5(6):520-30.
REF 5 CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. Neuron. 1998 Apr;20(4):693-707.
REF 6 Binding of neuroligins to PSD-95. Science. 1997 Sep 5;277(5331):1511-5.

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