Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T77127 Target Info
Target Name Vitamin D3 up-regulated protein 1 (VDUP1)
Synonyms Vitamin D(3) up-regulating protein-1; Thioredoxin-interacting protein; Thioredoxin-binding protein 2
Target Type Literature-reported Target
Gene Name TXNIP
Biochemical Class Arrestin protein
UniProt ID
TXNIP_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Ester hydrolases [+] 1 Ester hydrolases +
Other proteins [+] 1 Other proteins +
References  Top
REF 1 The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. J Biol Chem. 2010 Mar 19;285(12):8869-79.
REF 2 Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP. Biochem J. 2016 Jan 15;473(2):179-87.
REF 3 Identification of Redox and Glucose-Dependent Txnip Protein Interactions. Oxid Med Cell Longev. 2016;2016:5829063.
REF 4 VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene. 2003 Jun 26;22(26):4035-46.
REF 5 Vitamin D3 upregulated protein 1 suppresses TNF--induced NF-B activation in hepatocarcinogenesis. J Immunol. 2010 Oct 1;185(7):3980-9.
REF 6 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 7 Thioredoxin regulates adipogenesis through thioredoxin-interacting protein (Txnip) protein stability. J Biol Chem. 2011 Aug 19;286(33):29139-45.
REF 8 Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2). Exp Eye Res. 2007 Aug;85(2):270-9.
REF 9 Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-: a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1890-7.
REF 10 The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein. Nat Commun. 2014;5:2958.
REF 11 Structure of the N-terminal domain of human thioredoxin-interacting protein. Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):333-44.
REF 12 Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling. Endocrinology. 2006 Feb;147(2):733-43.
REF 13 TXNIP interacts with hEcd to increase p53 stability and activity. Biochem Biophys Res Commun. 2013 Aug 23;438(2):264-9.

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