Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78349 | Target Info | |||
| Target Name | ELAV-like protein 1 (ELAVL1) | ||||
| Synonyms | HuR; Hu-antigen R | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | ELAVL1 | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | Protein kinase C alpha (PRKCA) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Protein kinase C alpha type; Protein Kinase C alpha; PRKACA; PKC-alpha; PKCalpha; PKC-A; PKCA | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| Other proteins | [+] 3 Other proteins | + | |||
| Interacting Target Name | Beta-catenin (CTNNB1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Reconstituted Complex | [4] | |||
| Interacting Target Name | von Hippel-Lindau disease tumor suppressor (VHL) | Patented-recorded Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | pVHL; Protein G7 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [5] | |||
| 2 | Reconstituted Complex | [5] | |||
| Interacting Target Name | Polypyrimidine tract-binding protein (PTBP1) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | PTB; Polypyrimidine tract-binding protein 1; Polypyrimidine tractbinding protein 1; hnRNP I; Heterogeneous nuclear ribonucleoprotein I; 57 kDa RNA-binding protein PPTB-1; 57 kDa RNAbinding protein PPTB1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Yeast two hybrid | [7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The mRNA-stabilizing factor HuR protein is targeted by -TrCP protein for degradation in response to glycolysis inhibition. J Biol Chem. 2012 Dec 21;287(52):43639-50. | ||||
| REF 2 | Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2. Mol Biol Cell. 2007 Jun;18(6):2137-48. | ||||
| REF 3 | Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4. | ||||
| REF 4 | -Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells. Nucleic Acids Res. 2012 Aug;40(14):6863-72. | ||||
| REF 5 | Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma. Oncogene. 2005 Nov 24;24(53):7850-8. | ||||
| REF 6 | RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol. 2008 Jan;28(1):93-107. | ||||
| REF 7 | Dynamic protein-protein interaction wiring of the human spliceosome. Mol Cell. 2012 Feb 24;45(4):567-80. | ||||
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