Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T80886 | Target Info | |||
| Target Name | Transcription regulator protein BACH1 (Bach1) | ||||
| Synonyms | HA2303; BTB and CNC homolog 1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | BACH1 | ||||
| Biochemical Class | Basic leucine zipper bZIP | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Membrane-bounded channels | [+] 1 Membrane-bounded channels | + | |||
| Interacting Target Name | Exportin-1 (XPO1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Exp1; CRM1; Chromosome region maintenance 1 protein homolog | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| Transcription regulators | [+] 3 Transcription regulators | + | |||
| Interacting Protein Name | MAF bZIP transcription factor G (MAFG) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | hMAF | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Affinity Capture-MS | [4] | |||
| 3 | Affinity Capture-MS | [5] | |||
| 4 | Fluorescence Resonance Energy Transfer | [6] | |||
| Interacting Protein Name | MAF bZIP transcription factor K (MAFK) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | NFE2U; P18 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Affinity Capture-MS | [4] | |||
| 3 | Affinity Capture-MS | [5] | |||
| 4 | Affinity Capture-Western | [4] | |||
| Interacting Protein Name | MAF bZIP transcription factor F (MAFF) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | U.MAF; hMafF | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Affinity Capture-MS | [5] | |||
| 3 | Fluorescence Resonance Energy Transfer | [6] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | Hyaluronan mediated motility receptor (HMMR) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CD168; IHABP; RHAMM | ||||
| Evidence Score (E-score) | 5 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Affinity Capture-MS | [4] | |||
| 3 | Affinity Capture-MS | [5] | |||
| 4 | Affinity Capture-Western | [7] | |||
| 5 | Yeast two hybrid | [7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Elife. 2015 Dec 17;4. pii: e11466. | ||||
| REF 2 | Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling. Toxicology. 2016 Jul 1;363-364:48-57. | ||||
| REF 3 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 4 | Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Nat Struct Mol Biol. 2008 Dec;15(12):1246-54. | ||||
| REF 5 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23. | ||||
| REF 6 | Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science. 2013 May 10;340(6133):730-4. | ||||
| REF 7 | Dynamic cytoplasmic anchoring of the transcription factor Bach1 by intracellular hyaluronic acid binding protein IHABP. J Biochem. 2005 Mar;137(3):287-96. | ||||
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