Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T82028 Target Info
Target Name Sodium/hydrogen exchanger 1 (SLC9A1)
Synonyms Solute carrier family 9 member 1; Na+/H+ antiporter, amiloride-sensitive; Na(+)Sodium/hydrogen exchanger 1/H(+) exchanger 1; Na(+)/H(+) exchanger 1; Na(+)/H(+) antiporter, amiloride-sensitive; NHE1; NHE-1; Myocardial Na+/H+ exchanger; APNH1; APNH
Target Type Clinical trial Target
Gene Name SLC9A1
Biochemical Class Monovalent cation:proton antiporter-1
UniProt ID
SL9A1_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Calcineurin B homologous protein 1 (CHP1) Interacting Protein Interacting Protein Info
UniProt ID
CHP1_HUMAN 
Synonyms CHP; SLC9A1BP; Sid470p; p22; p24
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [4]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Calmodulin-1 (CALM1) Interacting Protein Interacting Protein Info
UniProt ID
CALM1_HUMAN 
Synonyms CALML2; CAMI; CPVT4; DD132; PHKD; caM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Far Western [6]
References  Top
REF 1 Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. Biol Pharm Bull. 2003 Feb;26(2):148-55.
REF 2 Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers. J Biol Chem. 2001 May 18;276(20):17367-72.
REF 3 Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells. Cell Signal. 2017 Jan;29:69-77.
REF 4 A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12631-6.
REF 5 Hypertonicity activates Na+/H+ exchange through Janus kinase 2 and calmodulin. J Biol Chem. 2003 May 9;278(19):16908-15.
REF 6 The Na+/H+ exchanger cytoplasmic tail: structure, function, and interactions with tescalcin. Biochemistry. 2003 Jun 24;42(24):7448-56.

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