Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T83145 Target Info
Target Name Nuclear factor NF-kappa-B (NFKB)
Synonyms Nuclear factor of kappa light polypeptide gene enhancer in B-cells; DNA-binding factor KBF
Target Type Successful Target
Gene Name NFKB1; NFKB2; RELA; RELB; REL
UniProt ID
NFKB1_HUMAN; NFKB2_HUMAN; TF65_HUMAN; RELB_HUMAN; REL_HUMAN 
Target Interacting Proteins  Top
Transcription regulators [+] 5 Transcription regulators +
Interacting Protein Name Transcription factor RelB (RELB) Interacting Protein Interacting Protein Info
UniProt ID
RELB_HUMAN 
Synonyms I.REL; IREL; REL.B
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Co-localization [3]
Interacting Target Name Signal transducer and activator of transcription 3 (STAT3) Successful Target Interacting Protein Info
UniProt ID
STAT3_HUMAN 
Synonyms Transcription factor STAT3; Stat3; Signal transducer and activator of transcription 3; APRF; Acute-phase response factor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Co-localization [5]
Interacting Target Name DNA-binding factor KBF1 (p105) Clinical trial Target Interacting Protein Info
UniProt ID
NFKB1_HUMAN 
Synonyms Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor of kappa light polypeptide gene enhancer in Bcells 1; Nuclear factor NFkappaB p50 subunit; Nuclear factor NF-kappa-B p105 subunit; Nuclear factor NFkappaB p105 subunit; EBP-1; EBP1; DNA-binding factor KBF1; DNAbinding factor KBF1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [6]
Interacting Target Name Proto-oncogene c-Rel (REL) Literature-reported Target Interacting Protein Info
UniProt ID
REL_HUMAN 
Synonyms C-Rel
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [7]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [7]
Other proteins [+] 3 Other proteins +
Interacting Target Name F-box and WD-40 domain protein 7 (Fbxw7) Literature-reported Target Interacting Protein Info
UniProt ID
FBXW7_HUMAN 
Synonyms SEL-10; SEL10; hCdc4; hAgo; FBX30; FBW7; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; F-box protein Fbxw6; F-box protein FBX30; F-box protein FBW7; F-box and WD-40 domain-containing protein 7; Archipelago homolog
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Interacting Protein Name B-cell lymphoma 3 protein (BCL3) Interacting Protein Interacting Protein Info
UniProt ID
BCL3_HUMAN 
Synonyms BCL4; D19S37
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [3]
2 Reconstituted Complex [8]
Interacting Protein Name F-box/WD repeat-containing protein 1A (BTRC) Interacting Protein Interacting Protein Info
UniProt ID
FBW1A_HUMAN 
Synonyms BETA.TRCP; FBW1A; FBXW1; FBXW1A; FWD1; bTrCP; bTrCP1; betaTrCP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Protein-peptide [10]
References  Top
REF 1 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol. 2004 Feb;6(2):97-105.
REF 2 Fbxw7- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol. 2012 Mar 4;14(4):375-85.
REF 3 Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma. Cancer Res. 2003 Dec 1;63(23):8293-301.
REF 4 Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7264-9.
REF 5 STAT3 cooperates with the non-canonical NF-B signaling to regulate pro-labor genes in the human placenta. Placenta. 2015 May;36(5):581-6.
REF 6 Positive and negative regulation of EAAT2 by NF-kappaB: a role for N-myc in TNFalpha-controlled repression. EMBO J. 2005 Feb 9;24(3):510-20.
REF 7 NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule. Mol Cell Biol. 1993 Oct;13(10):6089-101.
REF 8 The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell. 1993 Mar 12;72(5):729-39.
REF 9 Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100. J Biol Chem. 2002 Jun 21;277(25):22111-4.
REF 10 beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870. Cell Signal. 2006 Aug;18(8):1309-17.

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