Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T83904 Target Info
Target Name NAD-dependent deacetylase sirtuin-2 (SIRT2)
Synonyms SIR2like protein 2; SIR2L2; SIR2L; SIR2-like protein 2; Regulatory protein SIR2 homolog 2; NADdependent protein deacetylase sirtuin2; NAD-dependent protein deacetylase sirtuin-2
Target Type Patented-recorded Target
Gene Name SIRT2
Biochemical Class Carbon-nitrogen hydrolase
UniProt ID
SIR2_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Biochemical Activity [3]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Target Name Exportin-1 (XPO1) Clinical trial Target Interacting Protein Info
UniProt ID
XPO1_HUMAN 
Synonyms Exp1; CRM1; Chromosome region maintenance 1 protein homolog
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Protein-peptide [5]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Forkhead box protein O1A (FOXO1) Literature-reported Target Interacting Protein Info
UniProt ID
FOXO1_HUMAN 
Synonyms FOXO1A; Forkhead in rhabdomyosarcoma; Forkhead box protein O1A; Forkhead box protein O1; FKHR
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Biochemical Activity [7]
3 Reconstituted Complex [7]
References  Top
REF 1 Acetylation of Sirt2 by p300 attenuates its deacetylase activity. Biochem Biophys Res Commun. 2008 Oct 31;375(4):576-80.
REF 2 The SIRT2 deacetylase regulates autoacetylation of p300. Mol Cell. 2008 Nov 7;32(3):449-55.
REF 3 Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation. Nat Struct Mol Biol. 2013 Sep;20(9):1040-6.
REF 4 A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Elife. 2015 Dec 17;4. pii: e11466.
REF 5 Sequence and structural analyses of nuclear export signals in the NESdb database. Mol Biol Cell. 2012 Sep;23(18):3677-93.
REF 6 CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Mol Cancer Ther. 2014 Mar;13(3):687-98.
REF 7 Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10042-7.

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