Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T85158 Target Info
Target Name Lymphotoxin-alpha (LTA)
Synonyms Tumor necrosis factor ligand superfamily member 1; TNFSF1; TNFB; TNF-beta; LT-alpha
Target Type Clinical trial Target
Gene Name LTA
Biochemical Class Cytokine: tumor necrosis factor
UniProt ID
TNFB_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 2 Other proteins +
Interacting Target Name Lymphotoxin-beta (LTB) Literature-reported Target Interacting Protein Info
UniProt ID
TNFC_HUMAN 
Synonyms Tumor necrosis factor ligand superfamily member 3; Tumor necrosis factor C; TNF-C; LT-beta; LTB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [3]
Interacting Target Name Tumor necrosis factor receptor type I (TNF-R1) Clinical trial Target Interacting Protein Info
UniProt ID
TNR1A_HUMAN 
Synonyms Tumor necrosis factor-binding protein 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-RI; TNFR-I; TNFR1; TNFAR; TBPI; p60; p55; CD120a
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [4]
2 Reconstituted Complex [5]
References  Top
REF 1 Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors. J Immunol. 1995 Jan 1;154(1):33-46.
REF 2 The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand. J Biol Chem. 1997 Aug 1;272(31):19451-6.
REF 3 Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes. J Immunol. 1997 Oct 1;159(7):3288-98.
REF 4 Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell. 1993 May 7;73(3):431-45.
REF 5 Production of lymphotoxin (LT alpha) and a soluble dimeric form of its receptor using the baculovirus expression system. J Immunol Methods. 1994 Jan 12;168(1):79-89.

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