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| Target General Information |
Top |
| Target ID |
T86014 |
Target Info
|
| Target Name |
Sphingosine kinase 1 (SPHK1) |
| Synonyms |
SPK 1; SPK; SPHK1; SK 1; Acetyltransferase SPHK1 |
| Target Type |
Clinical trial Target |
| Gene Name |
SPHK1 |
| Biochemical Class |
Kinase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Acyltransferases |
[+] 1 Acyltransferases |
+ |
| Interacting Protein Name |
TNF receptor-associated factor 2 (TRAF2) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
MGC:45012; TRAP; TRAP3 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells. Autophagy. 2017 May 4;13(5):900-913.
|
| REF 2 |
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. J Biol Chem. 2002 Mar 8;277(10):7996-8003.
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