Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T87020 Target Info
Target Name FK506-binding protein 4 (FKBP4)
Synonyms p59; Peptidyl-prolyl cis-trans isomerase FKBP4; PPIase FKBP4; P59 protein; Immunophilin FKBP52; HSP-binding immunophilin; HSP binding immunophilin; HBI; FKBP59; FKBP52 protein; FKBP52; FKBP-52; FKBP-4; 59 kDa immunophilin; 52 kDa FKBP; 52 kDa FK506-binding protein; 52 kDa FK506 binding protein
Target Type Literature-reported Target
Gene Name FKBP4
Biochemical Class Cis-trans-isomerase
UniProt ID
FKBP4_HUMAN 
Target Interacting Proteins  Top
Heat shock proteins [+] 2 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [1]
4 Affinity Capture-Western [3]
5 Affinity Capture-Western [4]
6 Co-fractionation [5]
7 Reconstituted Complex [6]
8 Reconstituted Complex [7]
9 Reconstituted Complex [4]
10 Reconstituted Complex [8]
Interacting Target Name Heat shock protein 90 beta (HSP90B) Clinical trial Target Interacting Protein Info
UniProt ID
HS90B_HUMAN 
Synonyms HSP84; HSP 84; Heat shock 84 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [1]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Glucocorticoid receptor (NR3C1) Successful Target Interacting Protein Info
UniProt ID
GCR_HUMAN 
Synonyms Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Glomulin (GLMN) Interacting Protein Interacting Protein Info
UniProt ID
GLMN_HUMAN 
Synonyms FAP; FAP48; FAP68; FKBPAP; GLML; GVM; VMGLOM
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [11]
4 Reconstituted Complex [12]
5 Yeast two hybrid [13]
Interacting Protein Name Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) Interacting Protein Interacting Protein Info
UniProt ID
AHSA1_HUMAN 
Synonyms AHA1; C14orf3; p38
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [1]
3 Reconstituted Complex [7]
References  Top
REF 1 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell. 2014 Jul 17;158(2):434-448.
REF 2 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 3 Role of FAP48 in HIV-associated lipodystrophy. J Cell Biochem. 2012 Nov;113(11):3446-54.
REF 4 S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. FEBS Lett. 2010 Mar 19;584(6):1119-25.
REF 5 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 6 Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle. Nat Struct Mol Biol. 2011 Jan;18(1):61-6.
REF 7 Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Biochim Biophys Acta. 2012 Jun;1823(6):1092-101.
REF 8 Quantitative assessment of complex formation of nuclear-receptor accessory proteins. Biochem J. 2000 Feb 1;345 Pt 3:627-36.
REF 9 Ligand-specific glucocorticoid receptor activation in human platelets. Blood. 2005 Dec 15;106(13):4167-75.
REF 10 Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6839-43.
REF 11 The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2444-9.
REF 12 Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52. Regul Pept. 2001 Mar 2;97(2-3):147-52.
REF 13 Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-COA alpha-hydroxylase is a new FKBP-associated protein. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2104-9.

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