Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T88505 Target Info
Target Name Nuclear factor erythroid 2-related factor 2 (Nrf2)
Synonyms Nuclear factor, erythroid derived 2, like 2; NRF2; NFE2-related factor 2; NF-E2-related factor 2; HEBP1
Target Type Successful Target
Gene Name NFE2L2
Biochemical Class Basic leucine zipper bZIP
UniProt ID
NF2L2_HUMAN 
Target Interacting Proteins  Top
Transcription regulators [+] 3 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [3]
4 Reconstituted Complex [3]
5 Yeast two hybrid [1]
Interacting Protein Name MAF bZIP transcription factor G (MAFG) Interacting Protein Interacting Protein Info
UniProt ID
MAFG_HUMAN 
Synonyms hMAF
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Co-localization [4]
3 Fluorescence Resonance Energy Transfer [5]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [6]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Ectoderm-neural cortex protein 1 (ENC1) Interacting Protein Interacting Protein Info
UniProt ID
ENC1_HUMAN 
Synonyms CCL28; ENC.1; KLHL35; KLHL37; NRPB; PIG10; TP53I10
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Co-localization [8]
5 Reconstituted Complex [7]
6 Reconstituted Complex [8]
References  Top
REF 1 Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells. 2001 Oct;6(10):857-68.
REF 2 NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim Biophys Acta. 2008 May;1783(5):713-27.
REF 3 Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol. 2009 May;29(10):2658-72.
REF 4 Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. J Biol Chem. 2012 Oct 19;287(43):36341-55.
REF 5 Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science. 2013 May 10;340(6133):730-4.
REF 6 Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Oncogene. 1998 Dec 17;17(24):3145-56.
REF 7 The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells. Cancer Res. 2007 Sep 15;67(18):8596-604.
REF 8 NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors. Oncogene. 2009 Jan 22;28(3):378-89.
REF 9 Nuclear matrix protein (NRP/B) modulates the nuclear factor (Erythroid-derived 2)-related 2 (NRF2)-dependent oxidative stress response. J Biol Chem. 2010 Aug 20;285(34):26190-8.

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