| References |
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| REF 1 |
AMPylation of Rho GTPases subverts multiple host signaling processes. J Biol Chem. 2014 Nov 21;289(47):32977-88.
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| REF 2 |
IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J. 2012 Jan 4;31(1):14-28.
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| REF 3 |
cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation. Oncogene. 2014 Nov 27;33(48):5534-45.
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| REF 4 |
The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1. Dev Cell. 2011 Nov 15;21(5):959-65.
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| REF 5 |
The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation. Oncogene. 2013 Mar 28;32(13):1735-42.
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| REF 6 |
Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation. Sci Rep. 2017 Mar 20;7:44779.
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| REF 7 |
Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. J Biol Chem. 2012 Jan 13;287(3):2247-56.
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| REF 8 |
A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5.
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| REF 9 |
Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis. Curr Biol. 2000 Nov 2;10(21):1383-6.
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| REF 10 |
Purification and identification of G protein-coupled receptor protein complexes under native conditions. Mol Cell Proteomics. 2007 May;6(5):835-44.
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| REF 11 |
Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. J Pineal Res. 2016 Jan;60(1):95-108.
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| REF 12 |
Integrin 7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion. Blood. 2011 Jun 9;117(23):6202-13.
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| REF 13 |
Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. J Biol Chem. 1998 Apr 10;273(15):8776-82.
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| REF 14 |
The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2. Traffic. 2010 Feb;11(2):198-209.
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| REF 15 |
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491.
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| REF 16 |
RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility. J Biol Chem. 2012 Apr 20;287(17):13752-60.
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| REF 17 |
Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation. Biochemistry. 2001 Aug 28;40(34):10007-13.
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| REF 18 |
Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex. Biochemistry. 2001 Aug 28;40(34):10014-22.
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| REF 19 |
A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
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| REF 20 |
IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 1996 Jun 17;15(12):2997-3005.
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| REF 21 |
Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. J Biol Chem. 1996 Sep 20;271(38):23363-7.
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| REF 22 |
Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. EMBO J. 2006 May 17;25(10):2062-74.
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| REF 23 |
Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor. J Biol Chem. 2001 May 25;276(21):18303-12.
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| REF 24 |
Identification of a novel Rac1-interacting protein involved in membrane ruffling. EMBO J. 1996 Aug 1;15(15):3778-86.
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| REF 25 |
Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1. Biochem Biophys Res Commun. 2001 Aug 3;285(5):1267-73.
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| REF 26 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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| REF 27 |
SmgGDS displays differential binding and exchange activity towards different Ras isoforms. Oncogene. 2002 Apr 4;21(15):2425-32.
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| REF 28 |
The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho famil... Mol Cell Biol. 1996 Sep;16(9):4869-78.
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| REF 29 |
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature. 2000 Dec 7;408(6813):682-8.
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| REF 30 |
Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors. J Biol Chem. 2001 Dec 14;276(50):47530-41.
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| REF 31 |
Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. EMBO J. 2004 Sep 1;23(17):3492-504.
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