Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T89793 | Target Info | |||
| Target Name | Transducin beta-like 1X-related protein 1 (TBL1XR1) | ||||
| Synonyms | Transducin betalike 1Xrelated protein 1; TBLR1; TBL1related protein 1; TBL1-related protein 1; Nuclear receptor corepressor/HDAC3 complexsubunit TBLR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; IRA1; Fboxlike/WD repeatcontaining protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | TBL1XR1 | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Carbon-nitrogen hydrolases | [+] 2 Carbon-nitrogen hydrolases | + | |||
| Interacting Target Name | Histone deacetylase 3 (HDAC3) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | SMAP45; RPD3-2; RPD32; HD3 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Affinity Capture-Western | [3] | |||
| Interacting Target Name | Histone deacetylase 5 (HDAC5) | Patented-recorded Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | KIAA0600; HD5; Antigen NY-CO-9 | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [4] | |||
| Transcription regulators | [+] 1 Transcription regulators | + | |||
| Interacting Protein Name | Nuclear receptor corepressor 1 (NCOR1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Affinity Capture-Western | [3] | |||
| 4 | Reconstituted Complex | [5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011 Mar;29(3):255-65. | ||||
| REF 2 | Function of multiple Lis-Homology domain/WD-40 repeat-containing proteins in feed-forward transcriptional repression by silencing mediator for retinoic and thyroid receptor/nuclear receptor corepressor complexes. Mol Endocrinol. 2008 May;22(5):1093-104. | ||||
| REF 3 | The mutational landscape of ocular marginal zone lymphoma identifies frequent alterations in TNFAIP3 followed by mutations in TBL1XR1 and CREBBP. Oncotarget. 2017 Mar 7;8(10):17038-17049. | ||||
| REF 4 | Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Mol Cell Proteomics. 2011 Feb;10(2):M110.004317. | ||||
| REF 5 | Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J. 2003 Mar 17;22(6):1336-46. | ||||
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