Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T89873 Target Info
Target Name Ferritin (FTH1)
Synonyms PIG15; OK/SW-cl.84; Ferritin heavy chain; Ferritin H subunit; FTHL6; FTH; Cell proliferationinducing gene 15 protein; Cell proliferation-inducing gene 15 protein
Target Type Clinical trial Target
Gene Name FTH1
Biochemical Class Metal ion oxidoreductase
UniProt ID
FRIH_HUMAN 
Target Interacting Proteins  Top
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Protein Name Ferritin light chain (FTL) Interacting Protein Interacting Protein Info
UniProt ID
FRIL_HUMAN 
Synonyms LFTD; NBIA3
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
3 Yeast two hybrid [3]
4 Yeast two hybrid [4]
5 Yeast two hybrid [5]
6 Yeast two hybrid [6]
Other proteins [+] 1 Other proteins +
Interacting Target Name Nuclear receptor coactivator 4 (NCOA4) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA4_HUMAN 
Synonyms RFG; Ret-activating protein ELE1; Nuclear receptor coactivator 4; NCoA-4; ELE1; ARA70 (dARA70N); ARA70; Androgen receptor-associated protein of 70 kDa; Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; 70 kDa androgen receptor coactivator
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [7]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 3 Next-generation sequencing to generate interactome datasets. Nat Methods. 2011 Jun;8(6):478-80.
REF 4 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 5 Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 2015 Apr 23;161(3):647-660.
REF 6 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 7 Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. Elife. 2015 Oct 5;4.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.