Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T90553 Target Info
Target Name Microtubule affinity regulating kinase 3 (MARK3)
Synonyms cTAK1; Serine/threonine-protein kinase p78; Ser/Thr protein kinase PAR-1; Protein kinase STK10); Protein kinase STK10; Par-1a; MAP/microtubule affinity-regulating kinase 3; EMK2; EMK-2; ELKL motif kinase 2; Cdc25C-associated protein kinase 1; C-TAK1
Target Type Clinical trial Target
Gene Name MARK3
Biochemical Class Kinase
UniProt ID
MARK3_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name M-phase inducer phosphatase 3 (MPIP3) Literature-reported Target Interacting Protein Info
UniProt ID
MPIP3_HUMAN 
Synonyms Dual specificity phosphatase Cdc25C; Cdc25C phosphatase
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [1]
2 Biochemical Activity [3]
3 Biochemical Activity [4]
4 Reconstituted Complex [4]
Kinases [+] 1 Kinases +
Interacting Target Name Serine/threonine-protein kinase pim-1 (PIM1) Clinical trial Target Interacting Protein Info
UniProt ID
PIM1_HUMAN 
Synonyms PIM; Pim-1 proto-oncogene, serine/threonine kinase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Biochemical Activity [3]
3 Yeast two hybrid [3]
Proteins 14-3-3 [+] 1 Proteins 14-3-3 +
Interacting Target Name AS1 14-3-3 protein eta (YWHAH) Literature-reported Target Interacting Protein Info
UniProt ID
1433F_HUMAN 
Synonyms YWHA1; Protein AS1; 14-3-3 protein eta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [7]
References  Top
REF 1 Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation. J Cell Sci. 2006 Oct 1;119(Pt 19):4059-70.
REF 2 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3.
REF 3 The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. J Biol Chem. 2004 Nov 12;279(46):48319-28.
REF 4 C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ. 1998 Mar;9(3):197-208.
REF 5 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 6 Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J Biol Chem. 2004 Mar 26;279(13):12804-11.
REF 7 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J. 2010 Sep 15;430(3):393-404.

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