Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T91624 Target Info
Target Name Transcription intermediary factor 1-beta (TRIM28)
Synonyms Tripartite motif-containing protein 28; TIF1B; TIF1-beta; RNF96; RING-type E3 ubiquitin transferase TIF1-beta; RING finger protein 96; Nuclear corepressor KAP-1; KRIP-1; KRAB-interacting protein 1; KRAB-associated protein 1; KAP1; KAP-1; E3 SUMO-protein ligase TRIM28
Target Type Literature-reported Target
Gene Name TRIM28
Biochemical Class TRIM/RBCC family
UniProt ID
TIF1B_HUMAN 
Target Interacting Proteins  Top
Carbon-nitrogen hydrolases [+] 2 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-fractionation [2]
Interacting Target Name NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Interacting Protein Info
UniProt ID
SIR1_HUMAN 
Synonyms SIR2-like protein 1; SIR2L1; Regulatory protein SIR2 homolog 1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; hSIR2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Biochemical Activity [4]
Kinases [+] 1 Kinases +
Interacting Target Name ATM serine/threonine kinase (ATM) Clinical trial Target Interacting Protein Info
UniProt ID
ATM_HUMAN 
Synonyms Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Co-localization [6]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name Enhancer of zeste homolog 2 (EZH2) Successful Target Interacting Protein Info
UniProt ID
EZH2_HUMAN 
Synonyms Lysine N-methyltransferase 6; Lysine Nmethyltransferase 6; KMT6; Histone-lysine N-methyltransferase EZH2; Histonelysine Nmethyltransferase EZH2; EZH2 Y641N mutations; EZH2 Y641F mutations; ENX-1; ENX1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
3 Co-localization [8]
4 Reconstituted Complex [8]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [10]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [11]
Other proteins [+] 2 Other proteins +
Interacting Target Name Melanoma-associated antigen C2 (MAGEC2) Clinical trial Target Interacting Protein Info
UniProt ID
MAGC2_HUMAN 
Synonyms MAGE-E1 antigen; MAGEE1 antigen; MAGEE1; MAGE-C2 antigen; MAGEC2 antigen; Hepatocellular carcinoma-associated antigen 587; Hepatocellular carcinomaassociated antigen 587; HCA587; CT10; Cancer/testis antigen 10
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [13]
3 Reconstituted Complex [12]
4 Yeast two hybrid [13]
Interacting Target Name Melanoma-associated antigen 3 (MAGEA3) Clinical trial Target Interacting Protein Info
UniProt ID
MAGA3_HUMAN 
Synonyms Melanoma associated antigen-A3; Melanoma antigen 3; MAGE-A3 antigen; MAGE-A3; MAGE-3 antigen; MAGE3; CT1.3; Cancer/testis antigen 1.3; Antigen MZ2-D
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Yeast two hybrid [13]
References  Top
REF 1 The TRIM family protein KAP1 inhibits HIV-1 integration. Cell Host Microbe. 2011 Jun 16;9(6):484-95.
REF 2 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 3 USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell. 2012 May 25;46(4):484-94.
REF 4 KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair. PLoS One. 2015 Apr 23;10(4):e0123935.
REF 5 MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair. J Invest Dermatol. 2013 Mar;133(3):759-767.
REF 6 Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells. PLoS Pathog. 2017 Mar 1;13(3):e1006249.
REF 7 The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127.
REF 8 TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation. Oncogene. 2017 May 25;36(21):2991-3001.
REF 9 The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Rep. 2016 Jun 28;16(1):37-47.
REF 10 A unique SUMO-2-interacting motif within LANA is essential for KSHV latency. PLoS Pathog. 2013;9(11):e1003750.
REF 11 MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J. 2005 Sep 21;24(18):3279-90.
REF 12 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell. 2010 Sep 24;39(6):963-74.
REF 13 Identification of novel small molecules that inhibit protein-protein interactions between MAGE and KAP-1. Arch Biochem Biophys. 2011 Apr 15;508(2):217-21.

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