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| Target General Information |
Top |
| Target ID |
T92105 |
Target Info
|
| Target Name |
E3 ubiquitin-protein ligase RNF6 (RNF6) |
| Synonyms |
SPG2; RING-type E3 ubiquitin transferase RNF6 |
| Target Type |
Literature-reported Target |
| Gene Name |
RNF6 |
| Biochemical Class |
RNF12 family |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Nuclear hormone receptors |
[+] 1 Nuclear hormone receptors |
+ |
| Interacting Target Name |
Androgen receptor (AR) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Co-localization |
[2] |
| 3 |
Reconstituted Complex |
[1] |
| References |
Top |
| REF 1 |
Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer Cell. 2009 Apr 7;15(4):270-82.
|
| REF 2 |
Ring Finger Protein 6 Mediates Androgen-Induced Granulosa Cell Proliferation and Follicle Growth via Modulation of Androgen Receptor Signaling. Endocrinology. 2017 Apr 1;158(4):993-1004.
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