Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92517 | Target Info | |||
| Target Name | Calpain-1 (CAPN1) | ||||
| Synonyms | muCANP; PIG30; Micromolar-calpain; Cell proliferation-inducing gene 30 protein; Calpain-1 large subunit; Calpain-1 catalytic subunit; Calpain mu-type; Calcium-activated neutral proteinase 1; CANPL1; CANP 1 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | CAPN1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Intermediate filaments | [+] 1 Intermediate filaments | + | |||
| Interacting Protein Name | Vimentin (VIM) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CTRCT30; HEL113 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Yeast two hybrid | [2] | |||
| Lyases | [+] 1 Lyases | + | |||
| Interacting Protein Name | Enoyl-CoA hydratase 1 (ECHS1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | SCEH | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Co-fractionation | [3] | |||
| 2 | Yeast two hybrid | [2] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | Calpastatin (CAST) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | BS.17 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-MS | [4] | |||
| 3 | Affinity Capture-Western | [5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 2 | Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system. Hypertens Res. 2002 Jul;25(4):647-52. | ||||
| REF 3 | A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9. | ||||
| REF 4 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23. | ||||
| REF 5 | Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. Mol Cell Biol. 2010 Oct;30(19):4575-94. | ||||
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