Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T93580 Target Info
Target Name Regulator of G-protein signaling 4 (RGS4)
Synonyms RGP4
Target Type Literature-reported Target
Gene Name RGS4
UniProt ID
RGS4_HUMAN 
Target Interacting Proteins  Top
Guanine nucleotide-binding [+] 2 Guanine nucleotide-binding +
Interacting Target Name Guanine nucleotide-binding alpha-q (GNAQ) Literature-reported Target Interacting Protein Info
UniProt ID
GNAQ_HUMAN 
Synonyms GNAQ; G alphaq; G alpha(q)
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
3 Reconstituted Complex [2]
4 Reconstituted Complex [3]
Interacting Protein Name Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1) Interacting Protein Interacting Protein Info
UniProt ID
GNAI1_HUMAN 
Synonyms Gi
Evidence Score (E-score) 2 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [4]
2 Reconstituted Complex [2]
Kinases [+] 1 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [5]
2 Protein-Fragment Complementation Assay [6]
3 Yeast two hybrid [7]
References  Top
REF 1 RGS16 inhibits signalling through the G alpha 13-Rho axis. Nat Cell Biol. 2003 Dec;5(12):1095-103.
REF 2 Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane. J Biol Chem. 1998 Jul 17;273(29):18405-10.
REF 3 Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq. Mol Pharmacol. 2000 Apr;57(4):826-31.
REF 4 Fluorescence-based assay probing regulator of G protein signaling partner proteins. Anal Biochem. 2012 Apr 1;423(1):133-40.
REF 5 RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation. J Biol Chem. 2001 Dec 21;276(51):48532-8.
REF 6 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 7 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.