Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T93903 Target Info
Target Name Caspase-9 (CASP9)
Synonyms MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease activating factor 3; Apoptotic protease Mch-6; APAF-3
Target Type Clinical trial Target
Gene Name CASP9
Biochemical Class Peptidase
UniProt ID
CASP9_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 4 Acyltransferases +
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Biochemical Activity [5]
6 Co-crystal Structure [6]
7 Co-localization [7]
8 Far Western [8]
9 Reconstituted Complex [9]
10 Yeast two hybrid [10]
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Co-crystal Structure [12]
3 Co-localization [7]
4 Protein-peptide [12]
5 Reconstituted Complex [11]
6 Yeast two hybrid [13]
Interacting Target Name Cellular inhibitor of apoptosis 2 (BIRC3) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC3_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 1; TNFR2TRAFsignaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; hIAP-1; hIAP1; C-IAP2; CIAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Co-localization [7]
3 Reconstituted Complex [11]
4 Yeast two hybrid [14]
Interacting Target Name Melanoma inhibitor of apoptosis protein (ML-IAP) Patented-recorded Target Interacting Protein Info
UniProt ID
BIRC7_HUMAN 
Synonyms UNQ5800/PRO19607/PRO21344; RNF50; RING-type E3 ubiquitin transferase BIRC7; RING finger protein 50; MLIAP; Livin; Kidney inhibitor of apoptosis protein; KIAP; Baculoviral IAP repeat-containing protein 7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Yeast two hybrid [13]
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Target Name Apoptosis regulator Bcl-xL (BCL-xL) Clinical trial Target Interacting Protein Info
UniProt ID
B2CL1_HUMAN 
Synonyms Bcl-XL; BCLX; Bcl-2-like protein 1; Bcl2like protein 1; Bcl2-L-1; Bcl2L1; BCL2L; Apoptosis regulator Bcl-X
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Co-localization [7]
Peptidases [+] 1 Peptidases +
Interacting Target Name Caspase-3 (CASP3) Clinical trial Target Interacting Protein Info
UniProt ID
CASP3_HUMAN 
Synonyms Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; CPP-32; CPP32; Caspase 3; CASP-3; Apopain
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [17]
2 Co-localization [7]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Protein Name Baculoviral IAP repeat-containing protein 8 (BIRC8) Interacting Protein Interacting Protein Info
UniProt ID
BIRC8_HUMAN 
Synonyms ILP.2; ILP2; hILP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [9]
2 Yeast two hybrid [13]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Apoptotic protease-activating factor 1 (APAF1) Interacting Protein Interacting Protein Info
UniProt ID
APAF_HUMAN 
Synonyms APAF.1; CED4
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Affinity Capture-Western [19]
3 Affinity Capture-Western [20]
4 Affinity Capture-Western [21]
5 Yeast two hybrid [21]
Interacting Target Name Apoptosis inhibitor survivin (BIRC5) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC5_HUMAN 
Synonyms Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; API4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Co-localization [7]
References  Top
REF 1 A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature. 2001 Mar 1;410(6824):112-6.
REF 2 Expression of B-crystallin overrides the anti-apoptotic activity of XIAP. Neuro Oncol. 2012 Nov;14(11):1332-45.
REF 3 Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein. J Biol Chem. 2003 Dec 26;278(52):52660-72.
REF 4 BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis. Cancer Res. 2005 Dec 1;65(23):10657-62.
REF 5 X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO. J Biochem. 2005 Feb;137(2):125-32.
REF 6 Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell. 2003 Feb;11(2):519-27.
REF 7 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 8 Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9. J Biol Chem. 2004 Sep 24;279(39):40622-8.
REF 9 Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Mol Cell Biol. 2001 Jul;21(13):4292-301.
REF 10 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22;12(4):863.
REF 11 IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998 Apr 15;17(8):2215-23.
REF 12 The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):58-66.
REF 13 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 14 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 15 Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem. 2001 Feb 2;276(5):3238-46.
REF 16 Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4386-91.
REF 17 Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem J. 2007 Jul 1;405(1):11-9.
REF 18 Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997 Nov 14;91(4):479-89.
REF 19 A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. J Biol Chem. 2001 Mar 23;276(12):9239-45.
REF 20 XIAP associates with GSK3 and inhibits the promotion of intrinsic apoptotic signaling by GSK3. Cell Signal. 2009 Dec;21(12):1857-65.
REF 21 The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation. Cancer Lett. 2017 Sep 28;404:44-52.
REF 22 Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13103-7.

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