Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T93945 Target Info
Target Name Caveolin 1 (CAV1)
Synonyms Caveolin1; Caveolin-1; Cav-1
Target Type Literature-reported Target
Gene Name CAV1
Biochemical Class Caveolin protein
UniProt ID
CAV1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Valosin-containing protein p97 (VCP) Clinical trial Target Interacting Protein Info
UniProt ID
TERA_HUMAN 
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Co-localization [1]
4 Reconstituted Complex [2]
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Target Name Voltage-gated potassium channel Kv1.3 (KCNA3) Clinical trial Target Interacting Protein Info
UniProt ID
KCNA3_HUMAN 
Synonyms Voltage-gated potassium channel subunit Kv1.3; Voltage-gated Kv1.3 K(+) channel; Voltage-gated K(+) channel Kv1.3; Potassium channel Kv1.3; KCNA3; HuKIII; HPCN3; HLK3; HGK5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Fluorescence Resonance Energy Transfer [4]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Caveolin-2 (CAV2) Interacting Protein Interacting Protein Info
UniProt ID
CAV2_HUMAN 
Synonyms CAV
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Co-fractionation [6]
Ester hydrolases [+] 3 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-2 (PTPN11) Clinical trial Target Interacting Protein Info
UniProt ID
PTN11_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 11; SH-PTP3; SH-PTP2; SHPTP2; SHP-2; SHP2; PTP-2C; PTP2C; PTP-1D; Protein-tyrosine phosphatase SHP2; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase 1D
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [7]
3 Reconstituted Complex [8]
Interacting Target Name Serine/threonine PP2A-alpha (PPP2CA) Clinical trial Target Interacting Protein Info
UniProt ID
PP2AA_HUMAN 
Synonyms Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; RP-C; Replication protein C; PP2A-alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
Interacting Target Name Phospholipase D2 (PLD2) Clinical trial Target Interacting Protein Info
UniProt ID
PLD2_HUMAN 
Synonyms PLD1C; PLD 2; Phosphatidylcholine-hydrolyzing phospholipase D2; hPLD2; Choline phosphatase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Co-fractionation [12]
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Interacting Target Name Proteinase activated receptor 1 (F2R) Successful Target Interacting Protein Info
UniProt ID
PAR1_HUMAN 
Synonyms TR; Thrombin receptor; Proteinase-activated receptor 1; Protease-activated receptor-1; Protease activated receptor 1; PAR-1; PAR1; Coagulation factor II receptor; CF2R
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Co-fractionation [13]
Kinases [+] 2 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [15]
3 Affinity Capture-Western [16]
4 Co-fractionation [17]
5 Protein-Fragment Complementation Assay [18]
6 Reconstituted Complex [17]
7 Yeast two hybrid [19]
Interacting Target Name Tyrosine-protein kinase CSK (CSK) Patented-recorded Target Interacting Protein Info
UniProt ID
CSK_HUMAN 
Synonyms Protein-tyrosine kinase CYL; C-Src kinase
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Reconstituted Complex [7]
3 Yeast two hybrid [20]
Nuclear hormone receptors [+] 2 Nuclear hormone receptors +
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Co-fractionation [21]
3 Co-localization [21]
4 Yeast two hybrid [21]
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Co-localization [23]
3 Reconstituted Complex [22]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name Prostaglandin G/H synthase 2 (COX-2) Successful Target Interacting Protein Info
UniProt ID
PGH2_HUMAN 
Synonyms Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PHS II; PGHS-2; PGH synthase 2; Cytochrome c oxidase polypeptide II; Cyclooxygenase-2; COX2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Affinity Capture-Western [25]
3 Affinity Capture-Western [2]
4 Co-fractionation [24]
5 Reconstituted Complex [24]
6 Reconstituted Complex [2]
References  Top
REF 1 Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase. J Biol Chem. 2013 Mar 8;288(10):7363-72.
REF 2 Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex. J Biol Chem. 2013 Nov 15;288(46):33462-9.
REF 3 Kv1.5 association modifies Kv1.3 traffic and membrane localization. J Biol Chem. 2008 Mar 28;283(13):8756-64.
REF 4 Caveolin interaction governs Kv1.3 lipid raft targeting. Sci Rep. 2016 Mar 2;6:22453.
REF 5 Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. J Biol Chem. 1997 Nov 14;272(46):29337-46.
REF 6 Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells. Biochemistry. 2008 Jan 8;47(1):101-11.
REF 7 SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. PLoS One. 2014 Mar 14;9(3):e91582.
REF 8 Protein-protein interaction between caveolin-1 and SHP-2 is dependent on the N-SH2 domain of SHP-2. BMB Rep. 2015 Mar;48(3):184-9.
REF 9 Identification of a novel inhibitor of differentiation-1 (ID-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cells. J Biol Chem. 2007 Nov 16;282(46):33284-94.
REF 10 Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Mol Cell Biol. 2003 Dec;23(24):9389-404.
REF 11 Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation. J Invest Dermatol. 2003 Dec;121(6):1487-95.
REF 12 Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains. FEBS Lett. 2000 Feb 11;467(2-3):326-32.
REF 13 Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells. J Thromb Haemost. 2007 Dec;5(12):2437-44.
REF 14 Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation ... Mol Cell Proteomics. 2006 Sep;5(9):1610-27.
REF 15 Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction. Am J Physiol Renal Physiol. 2003 Feb;284(2):F303-12.
REF 16 Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells. J Biol Chem. 2000 Jul 7;275(27):20847-52.
REF 17 Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae. Oncogene. 2004 Sep 9;23(41):6967-79.
REF 18 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 19 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 20 A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase. J Biol Chem. 2002 Mar 15;277(11):8771-4.
REF 21 The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor through spatial relocalization at helix 7 of its ligand-binding domain. Mol Cell Biol. 2011 Aug;31(16):3497-510.
REF 22 Ligand-independent activation of oestrogen receptor alpha by caveolin-1. Biochem J. 2001 Oct 1;359(Pt 1):203-10.
REF 23 Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor- interactions with G protein-i and caveolin I. Steroids. 2012 Apr;77(5):424-32.
REF 24 Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts. J Biol Chem. 2001 Sep 14;276(37):34975-82.
REF 25 Caveolin-1 facilitates cyclooxygenase-2 protein degradation. J Cell Biochem. 2010 Feb 1;109(2):356-62.

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