Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T94201 Target Info
Target Name SRSF protein kinase 1 (SRPK1)
Synonyms Serine/arginine-rich protein-specific kinase 1; SR-protein-specific kinase 1; SFRS protein kinase 1
Target Type Preclinical Target
Gene Name SRPK1
Biochemical Class Kinase
UniProt ID
SRPK1_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Ribonuclease 3 (DROSHA) Interacting Protein Interacting Protein Info
UniProt ID
RNC_HUMAN 
Synonyms ETOHI2; HSA242976; RANSE3L; RN3; RNASE3L; RNASEN
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Protein Name RNA-binding protein with serine-rich domain 1 (RNPS1) Interacting Protein Interacting Protein Info
UniProt ID
RNPS1_HUMAN 
Synonyms E5.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Fluorescence Resonance Energy Transfer [2]
Splicing factors [+] 3 Splicing factors +
Interacting Protein Name Serine/arginine-rich splicing factor 1 (SRSF1) Interacting Protein Interacting Protein Info
UniProt ID
SRSF1_HUMAN 
Synonyms ASF; SF2; SF2p33; SFRS1; SRp30a
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Biochemical Activity [5]
3 Biochemical Activity [2]
4 Biochemical Activity [6]
5 Biochemical Activity [4]
6 Biochemical Activity [7]
Interacting Protein Name Serine/arginine-rich splicing factor 2 (SRSF2) Interacting Protein Interacting Protein Info
UniProt ID
SRSF2_HUMAN 
Synonyms PR264; SC.35; SC35; SFRS2; SFRS2A; SRp30b
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Co-fractionation [8]
Interacting Protein Name Splicing factor U2AF 35 kDa subunit (U2AF1) Interacting Protein Interacting Protein Info
UniProt ID
U2AF1_HUMAN 
Synonyms FP793; RN; RNU2AF1; U2AF35; U2AFBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Yeast two hybrid [9]
Other proteins [+] 3 Other proteins +
Interacting Protein Name Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) Interacting Protein Interacting Protein Info
UniProt ID
HNRPC_HUMAN 
Synonyms C1; C2; HNRNP; HNRPC; SNRPC
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Co-fractionation [10]
Interacting Protein Name Pre-mRNA-splicing factor 38A (PRPF38A) Interacting Protein Interacting Protein Info
UniProt ID
PR38A_HUMAN 
Synonyms Prp38
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [2]
2 Yeast two hybrid [9]
Interacting Protein Name U1 small nuclear ribonucleoprotein 70 kDa (SNRNP70) Interacting Protein Interacting Protein Info
UniProt ID
RU17_HUMAN 
Synonyms RNPU1Z; RPU1; SNRP70; Snp1; U1.70K; U170K; U1AP; U1RNP
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [6]
2 Biochemical Activity [2]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
REF 3 TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Proc Natl Acad Sci U S A. 2014 May 13;111(19):6970-5.
REF 4 The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J Biol Chem. 1999 Apr 16;274(16):11125-31.
REF 5 Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. J Biol Chem. 2007 Aug 10;282(32):23036-43.
REF 6 SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J Cell Biol. 1998 Feb 23;140(4):737-50.
REF 7 Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Biochem Biophys Res Commun. 2003 Feb 7;301(2):324-9.
REF 8 Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. EMBO J. 2011 Feb 2;30(3):510-23.
REF 9 Dynamic protein-protein interaction wiring of the human spliceosome. Mol Cell. 2012 Feb 24;45(4):567-80.
REF 10 Identification of toposome, a novel multisubunit complex containing topoisomerase IIalpha. Cell Cycle. 2004 May;3(5):638-47.

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