Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T95183 Target Info
Target Name Ubiquitin carboxyl-terminal hydrolase 2 (USP2)
Synonyms Ubiquitin-specific-processing protease 2; Ubiquitin thioesterase 2; UBP41; Deubiquitinating enzyme 2; 41 kDa ubiquitin-specific protease
Target Type Preclinical Target
Gene Name USP2
Biochemical Class Peptidase
UniProt ID
UBP2_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 3 Acyltransferases +
Interacting Target Name Fatty acid synthase (FASN) Successful Target Interacting Protein Info
UniProt ID
FAS_HUMAN 
Synonyms Yeast fatty acid synthase; Fatty-acyl-CoA synthase; Fatty acyl-CoA synthetase enzyme; FAS
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [1]
4 Biochemical Activity [1]
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Biochemical Activity [4]
3 Biochemical Activity [3]
4 Yeast two hybrid [5]
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Biochemical Activity [7]
Kinases [+] 1 Kinases +
Interacting Target Name Receptor-interacting protein 1 (RIPK1) Clinical trial Target Interacting Protein Info
UniProt ID
RIPK1_HUMAN 
Synonyms RIP-1; RIP1; RIP; Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [7]
3 Biochemical Activity [7]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) Interacting Protein Interacting Protein Info
UniProt ID
MALT1_HUMAN 
Synonyms IMD12; MLT; MLT1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Biochemical Activity [8]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 18 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Biochemical Activity [4]
3 Biochemical Activity [10]
4 Biochemical Activity [11]
5 Biochemical Activity [12]
6 Biochemical Activity [13]
7 Biochemical Activity [14]
8 Biochemical Activity [15]
9 Biochemical Activity [16]
10 Biochemical Activity [17]
11 Biochemical Activity [18]
12 Biochemical Activity [19]
13 Biochemical Activity [20]
14 Co-crystal Structure [21]
15 Co-crystal Structure [22]
16 Protein-peptide [22]
17 Reconstituted Complex [15]
18 Reconstituted Complex [23]
References  Top
REF 1 The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell. 2004 Mar;5(3):253-61.
REF 2 The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer. Cell Cycle. 2012 Mar 15;11(6):1123-30.
REF 3 USP2a positively regulates TCR-induced NF-B activation by bridging MALT1-TRAF6. Protein Cell. 2013 Jan;4(1):62-70.
REF 4 Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol. 2010 Aug;17(8):939-47.
REF 5 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 6 De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1. Biochim Biophys Acta. 2012 Aug;1823(8):1353-65.
REF 7 De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. Cell Death Differ. 2012 May;19(5):891-9.
REF 8 Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation. PLoS One. 2017 Jan 4;12(1):e0169026.
REF 9 Large-scale analysis of the human ubiquitin-related proteome. Proteomics. 2005 Nov;5(16):4145-51.
REF 10 Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. EMBO J. 2015 Feb 3;34(3):307-25.
REF 11 Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep. 2009 May;10(5):466-73.
REF 12 The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability. Hum Mol Genet. 2011 Jan 1;20(1):141-54.
REF 13 Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry. Nat Methods. 2017 May;14(5):504-512.
REF 14 Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes. Biochemistry. 2016 Aug 23;55(33):4708-19.
REF 15 Transient kinetic analysis of USP2-catalyzed deubiquitination reveals a conformational rearrangement in the K48-linked diubiquitin substrate. Biochemistry. 2012 Dec 18;51(50):10075-86.
REF 16 Wss1 is a SUMO-dependent isopeptidase that interacts genetically with the Slx5-Slx8 SUMO-targeted ubiquitin ligase. Mol Cell Biol. 2010 Aug;30(15):3737-48.
REF 17 Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family. PLoS One. 2015 Nov 20;10(11):e0143227.
REF 18 Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins. Structure. 2016 Mar 1;24(3):423-36.
REF 19 The molecular determinants for distinguishing between ubiquitin and NEDD8 by USP2. Sci Rep. 2017 May 23;7(1):2304.
REF 20 Method for the Purification of Endogenous Unanchored Polyubiquitin Chains. Methods Mol Biol. 2016;1449:203-13.
REF 21 Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. Structure. 2006 Aug;14(8):1293-302.
REF 22 A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 1;339(6119):590-5.
REF 23 Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8705-10.

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