Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T95715 Target Info
Target Name Transcription factor E2-alpha (TCF3)
Synonyms bHLHb21; Transcription factor ITF-1; Transcription factor 3; TCF-3; Kappa-E2-binding factor; Immunoglobulin transcription factor 1; Immunoglobulin enhancer-binding factor E12/E47; ITF1; E2A; Class B basic helix-loop-helix protein 21
Target Type Literature-reported Target
Gene Name TCF3
UniProt ID
TFE2_HUMAN 
Target Interacting Proteins  Top
Transcription regulators [+] 3 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [1]
2 Protein-peptide [2]
3 Reconstituted Complex [3]
Interacting Target Name DNA-binding protein inhibitor ID-2 (ID2) Literature-reported Target Interacting Protein Info
UniProt ID
ID2_HUMAN 
Synonyms Inhibitor of DNA binding 2; Inhibitor of differentiation 2; Id2; Class B basic helix-loop-helix protein 26; bHLHb26
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [5]
3 Yeast two hybrid [6]
Interacting Protein Name Inhibitor of DNA binding 1 (ID1) Interacting Protein Interacting Protein Info
UniProt ID
ID1_HUMAN 
Synonyms Inhibitor of DNA binding 1; Inhibitor of differentiation 1; ID; DNA-binding protein inhibitor ID-1; Class B basic helix-loop-helix protein 24; bHLHb24
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Yeast two hybrid [6]
References  Top
REF 1 Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J Biol Chem. 2003 Jan 24;278(4):2370-6.
REF 2 Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation. Biochim Biophys Acta. 2012 May;1819(5):375-81.
REF 3 E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells. J Biol Chem. 2004 Dec 31;279(53):55362-71.
REF 4 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 5 Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5831-6.
REF 6 Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J Biol Chem. 1997 Aug 8;272(32):19785-93.
REF 7 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.

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