Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T96435 Target Info
Target Name Sentrin specific protease-1 (SENP1)
Synonyms Sentrin/SUMO-specific protease SENP1; Sentrin-specific protease 1
Target Type Literature-reported Target
Gene Name SENP1
Biochemical Class Peptidase
UniProt ID
SENP1_HUMAN 
Target Interacting Proteins  Top
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Protein Name Ran GTPase-activating protein 1 (RANGAP1) Interacting Protein Interacting Protein Info
UniProt ID
RAGP1_HUMAN 
Synonyms Fug1; RANGAP; SD
Evidence Score (E-score) 6 Experimental Evidences +
1 Biochemical Activity [1]
2 Biochemical Activity [2]
3 Biochemical Activity [3]
4 Co-crystal Structure [4]
5 Fluorescence Resonance Energy Transfer [4]
6 Reconstituted Complex [4]
Ubiquitin related proteins [+] 3 Ubiquitin related proteins +
Interacting Protein Name Small ubiquitin-related modifier 1 (SUMO1) Interacting Protein Interacting Protein Info
UniProt ID
SUMO1_HUMAN 
Synonyms DAP1; GMP1; OFC10; PIC1; SENP2; SMT3; SMT3C; SMT3H3; UBL1
Evidence Score (E-score) 9 Experimental Evidences +
1 Biochemical Activity [2]
2 Biochemical Activity [5]
3 Biochemical Activity [6]
4 Biochemical Activity [7]
5 Co-crystal Structure [4]
6 Fluorescence Resonance Energy Transfer [4]
7 Reconstituted Complex [4]
8 Reconstituted Complex [7]
9 Yeast two hybrid [8]
Interacting Protein Name Small ubiquitin-related modifier 2 (SUMO2) Interacting Protein Interacting Protein Info
UniProt ID
SUMO2_HUMAN 
Synonyms HSMT3; SMT3B; SMT3H2; SUMO3; Smt3A
Evidence Score (E-score) 7 Experimental Evidences +
1 Biochemical Activity [2]
2 Biochemical Activity [5]
3 Biochemical Activity [7]
4 Co-crystal Structure [2]
5 Fluorescence Resonance Energy Transfer [4]
6 Reconstituted Complex [4]
7 Reconstituted Complex [2]
Interacting Protein Name Small ubiquitin-related modifier 3 (SUMO3) Interacting Protein Interacting Protein Info
UniProt ID
SUMO3_HUMAN 
Synonyms SMT3A; SMT3H1; SUMO.3; Smt3B
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [2]
2 Biochemical Activity [6]
3 Biochemical Activity [7]
4 Reconstituted Complex [7]
References  Top
REF 1 Important role of SUMOylation of Spliceosome factors in prostate cancer cells. J Proteome Res. 2014 Aug 1;13(8):3571-82.
REF 2 The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem J. 2006 Jul 15;397(2):279-88.
REF 3 Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation. Oncotarget. 2016 Sep 13;7(37):58995-59005.
REF 4 SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol. 2006 Dec;13(12):1069-77.
REF 5 SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. J Cell Biol. 2006 Sep 25;174(7):939-49.
REF 6 Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. J Biol Chem. 2006 Jun 9;281(23):15869-77.
REF 7 Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. EMBO Rep. 2012 Oct;13(10):930-8.
REF 8 The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression. J Biol Chem. 2018 Oct 5;293(40):15439-15454.

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