Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97257 | Target Info | |||
| Target Name | Transforming growth factor beta 1 (TGFB1) | ||||
| Synonyms | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1; TGFB; TGF-beta1; TGF-beta 1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | TGFB1 | ||||
| Biochemical Class | Growth factor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 2 Kinases | + | |||
| Interacting Target Name | TGF-beta receptor type I (TGFBR1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; TbetaR-I; TbetaRI; SKR4; Serine/threonine-protein kinase receptor R4; ALK-5; ALK5; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Reconstituted Complex | [2] | |||
| Interacting Target Name | TGF-beta receptor type II (TGFBR2) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transforminggrowth factor-beta receptor type II; Transforming growth factor-beta receptor type II; TGFR-2; TGF-beta type II receptor; TGF-beta receptor type-2; TbetaR-II | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Reconstituted Complex | [4] | |||
| Peptidases | [+] 1 Peptidases | + | |||
| Interacting Target Name | Matrix metalloproteinase-2 (MMP-2) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | TBE-1; Matrix metalloproteinase 2; Gelatinase A; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [5] | |||
| 2 | Co-localization | [6] | |||
| Pore-forming toxins | [+] 1 Pore-forming toxins | + | |||
| Interacting Target Name | Amyloid beta A4 protein (APP) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Vascular beta-amyloid; Protease nexin-II; PreA4; PN-II; CVAP; Cerebral vascular amyloidpeptide; Cerebral vascular amyloid peptide; Beta-amyloid peptide; APPI; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Amyloid precursor protein; Amyloid beta precursor protein; Alzheimer's disease amyloid protein; Alzheimer disease amyloid protein; AD1; ABPP; A4 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [7] | |||
| 2 | Co-localization | [6] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | Laminin subunit beta-1 (LAMB1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CLM; LIS5 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [7] | |||
| 2 | Yeast two hybrid | [8] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Determination of type I receptor specificity by the type II receptors for TGF-beta or activin. Science. 1993 Nov 5;262(5135):900-2. | ||||
| REF 2 | Bikunin down-regulates heterodimerization between CD44 and growth factor receptors and subsequently suppresses agonist-mediated signaling. J Cell Biochem. 2005 Apr 1;94(5):995-1009. | ||||
| REF 3 | Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor. EMBO J. 2001 Feb 1;20(3):480-90. | ||||
| REF 4 | A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic ... J Biol Chem. 1993 Jun 15;268(17):12719-23. | ||||
| REF 5 | Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev. 2000 Jan 15;14(2):163-76. | ||||
| REF 6 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. | ||||
| REF 7 | Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4. | ||||
| REF 8 | A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5. | ||||
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