| References |
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Parkin regulates NF-B by mediating site-specific ubiquitination of RIPK1. Cell Death Dis. 2018 Jun 28;9(7):732.
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| REF 2 |
Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3. Cell Signal. 2016 Feb;28(2):72-80.
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| REF 3 |
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell. 2008 Jun 20;30(6):689-700.
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| REF 4 |
PPAR Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers. Mol Cancer Ther. 2017 Nov;16(11):2528-2542.
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| REF 5 |
A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell. 2009 Oct 23;36(2):302-14.
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| REF 6 |
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010 Dec 15;29(24):4198-209.
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| REF 7 |
X-linked inhibitor of apoptosis-associated factor 1 regulates TNF receptor 1 complex stability. FEBS Lett. 2016 Dec;590(23):4381-4392.
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TRAF2 is a biologically important necroptosis suppressor. Cell Death Differ. 2015 Nov;22(11):1846-57.
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| REF 9 |
The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas. J Cell Biol. 2011 Feb 7;192(3):391-9.
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| REF 10 |
TRIM38 inhibits TNF- and IL-1-triggered NF-B activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1509-14.
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| REF 11 |
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity. 1996 Apr;4(4):387-96.
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| REF 12 |
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature. 1997 Feb 6;385(6616):540-4.
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| REF 13 |
cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PLoS One. 2011;6(9):e22356.
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| REF 14 |
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature. 2004 Aug 5;430(7000):694-9.
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| REF 15 |
Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding. J Biol Chem. 2006 Nov 10;281(45):34592-600.
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| REF 16 |
A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation. J Biol Chem. 2002 May 3;277(18):15985-91.
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| REF 17 |
NEMO/IKKgamma regulates an early NF-kappaB-independent cell-death checkpoint during TNF signaling. Cell Death Differ. 2009 Sep;16(9):1279-88.
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| REF 18 |
NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF- feedforward signaling. Cell. 2011 Apr 1;145(1):92-103.
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| REF 19 |
The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells. Cell Death Dis. 2014 Feb 27;5:e1085.
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| REF 20 |
FADD regulates NF-B activation and promotes ubiquitination of cFLIPL to induce apoptosis. Sci Rep. 2016 Mar 14;6:22787.
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| REF 21 |
MiR-145 promotes TNF--induced apoptosis by facilitating the formation of RIP1-FADDcaspase-8 complex in triple-negative breast cancer. Tumour Biol. 2016 Jul;37(7):8599-607.
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| REF 22 |
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell. 2011 Aug 5;43(3):432-48.
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NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation. Cell Signal. 2008 Jun;20(6):1044-51.
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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell. 2004 Aug 27;15(4):535-48.
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Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem. 2001 Sep 28;276(39):36530-4.
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Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem. 2006 May 12;281(19):13636-43.
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A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. Mol Cell Biol. 2011 Jul;31(14):2774-86.
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| REF 28 |
Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization. J Biol Chem. 2000 Dec 1;275(48):37966-77.
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| REF 29 |
A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma. Cancer Discov. 2012 Feb;2(2):140-55.
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| REF 30 |
De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1. Biochim Biophys Acta. 2012 Aug;1823(8):1353-65.
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| REF 31 |
De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. Cell Death Differ. 2012 May;19(5):891-9.
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| REF 32 |
An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem. 2000 Sep 8;275(36):27823-31.
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| REF 33 |
Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-B activation and leads to incontinentia pigmenti. J Allergy Clin Immunol. 2017 Dec;140(6):1671-1682.e2.
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| REF 34 |
Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway. J Biol Chem. 2001 Jun 1;276(22):19012-9.
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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44.
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| REF 36 |
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity. 2003 May;18(5):655-64.
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Sam68 is required for both NF-B activation and apoptosis signaling by the TNF receptor. Mol Cell. 2011 Jul 22;43(2):167-79.
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Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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RAIDD is a new 'death' adaptor molecule. Nature. 1997 Jan 2;385(6611):86-9.
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