Target Validation Information
TTD ID	T04741
Target Name	Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC)
Type of Target	Literature-reported
Drug Potency against Target	FAICAR	Drug Info	Ki = 400 nM	[2]
	NSC-126445	Drug Info	IC50 = 9600 nM	[1]
	NSC-26699	Drug Info	IC50 = 16900 nM	[1]
	NSC-292213	Drug Info	IC50 = 8800 nM	[1]
	NSC-30171	Drug Info	Ki = 154 nM	[1]
	NSC-324572	Drug Info	IC50 = 11600 nM	[1]
	NSC-37031	Drug Info	IC50 = 7800 nM	[1]
	NSC-37173	Drug Info	IC50 = 4100 nM	[1]
	NSC-45592	Drug Info	IC50 = 11600 nM	[1]
	NSC-47729	Drug Info	IC50 = 3300 nM	[1]
	NSC-58046	Drug Info	IC50 = 7600 nM	[1]
	NSC-88915	Drug Info	IC50 = 13900 nM	[1]
References
REF 1	Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90.
REF 2	Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem. 2007 Apr 27;282(17):13033-46.

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