| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T06011 | ||||
| Target Name | Transforming growth factor beta (TGFB) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | Pirfenidone | Drug Info | IC50 = 44.3 ug/ml | ||
| Action against Disease Model | GC-1008 | Drug Info | With the help of a proliferation assay with MLEC cells, the IC50 values for GC-1008 against the different TGF-|??isoforms were determined: for TGF-beta1,IC50=1 ???2nM;for TGF-beta2,IC50=14 ???5nM;for TGF-beta3,IC50=7 ???2nM. | [1] | |
| References | |||||
| REF 1 | A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20251-6. | ||||
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