| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T07173 | ||||
| Target Name | Tropomyosin-related kinase A (TrkA) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | CEP-5104 | Drug Info | IC50 = 1270 nM | [2] | |
| CEP-6331 | Drug Info | IC50 = 1055 nM | [2] | ||
| GW-5074 | Drug Info | IC50 = 4700 nM | [1] | ||
| References | |||||
| REF 1 | Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7. | ||||
| REF 2 | Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. | ||||
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