Target Validation Information
TTD ID	T07217
Target Name	Fatty acid-binding protein 4 (FABP4)
Type of Target	Patented-recorded
Drug Potency against Target	1-benzyl-2,3-dimethyl-1H-indole-7-carboxylic acid	Drug Info	IC50 = 3600 nM	[3]
	2-(2,3-bis(2-chlorobenzyloxy)phenyl)acetic acid	Drug Info	Ki = 16 nM	[2]
	2-(3-Methyl-indole-1-sulfonyl)-benzoic acid	Drug Info	IC50 = 8500 nM	[1]
	2-(4-Fluoro-indole-1-sulfonyl)-benzoic acid	Drug Info	IC50 = 10000 nM	[1]
	2-(4-Methyl-indole-1-sulfonyl)-benzoic acid	Drug Info	IC50 = 12000 nM	[1]
	2-(5-Bromo-indole-1-sulfonyl)-benzoic acid	Drug Info	IC50 = 12000 nM	[1]
	2-(6-Methoxy-indole-1-sulfonyl)-benzoic acid	Drug Info	IC50 = 6100 nM	[1]
	2-(Carbazole-9-sulfonyl)-benzoic acid	Drug Info	IC50 = 4300 nM	[1]
	3-Carbazol-9-yl-propionic acid	Drug Info	IC50 = 9400 nM	[1]
	4-Carbazol-9-yl-butyric acid	Drug Info	IC50 = 570 nM	[1]
	5-Carbazol-9-yl-pentanoic acid	Drug Info	IC50 = 800 nM	[1]
	BMS-480404	Drug Info	Ki = 2.5 nM	[2]
	Hexadecanoic acid	Drug Info	IC50 = 930 nM	[1]
	LINOLEIC ACID	Drug Info	IC50 = 1000 nM	[4]
References
REF 1	Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8.
REF 2	NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein. J Med Chem. 2006 Aug 10;49(16):5013-7.
REF 3	N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1745-8.
REF 4	Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9.

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