Target Validation Information
TTD ID	T10735
Target Name	Histidine decarboxylase (HDC)
Type of Target	Clinical trial
Action against Disease Model	Brocresine	Drug Info	Brocresine (NSD-1055) was found to be an effective inhibitor of histidine decarboxylase. With the fairly high dose given (200 mg/kg) the inhibition of histidine decarboxylase was at most 75-85% and quite short-lasting. The DOPA decarboxylase activity, which was not affected by vagal denervation, was inhibited more than 95% by brocresine; this inhibition was longer-lasting.	[1]
References
REF 1	Effects of brocresine (NSD-1055) and cycloheximide on amino acid decarboxylase activities in gastric mucosa of normal and vagally denervated rats. Br J Pharmacol. 1972 Dec;46(4):688-95.

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