Target Validation Information
TTD ID	T10897
Target Name	Acyl-CoA desaturase (SCD)
Type of Target	Successful
Drug Potency against Target	2-(4-benzoylpiperazin-1-yl)thiazole-5-carboxamide	Drug Info	IC50 = 2000 nM	[2]
	CVT-12012	Drug Info	IC50 = 38 nM	[1]
	CVT-12012	Drug Info	IC50 = 6.1 nM	[1]
	MF-152	Drug Info	IC50 = 106 nM	[4]
	MF-152	Drug Info	IC50 = 2.3 nM	[3]
	MF-152	Drug Info	IC50 = 254 nM	[4]
References
REF 1	Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4070-4.
REF 2	Thiazole analog as stearoyl-CoA desaturase 1 inhibitor. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5214-7.
REF 3	Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.
REF 4	SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1593-7.

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