Target Validation Information
TTD ID	T11288
Target Name	Multidrug resistance-associated protein 1 (ABCC1)
Type of Target	Successful
Drug Potency against Target	Sulfinpyrazone	Drug Info	IC50 = 420 uM	[3]
	L-660771	Drug Info	IC50 = 7570 nM	[2]
	XR-9456	Drug Info	IC50 = 300 nM	[1]
	XR-9504	Drug Info	IC50 = 260 nM	[1]
	XR-9544	Drug Info	IC50 = 50 nM	[1]
	XR-9577	Drug Info	IC50 = 320 nM	[1]
References
REF 1	Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62.
REF 2	A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4761-3.
REF 3	Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol. 2003 May;63(5):1094-103.

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