| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T11822 | ||||
| Target Name | Retinoic acid receptor (RAR) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Vitamin A | Drug Info | IC50 = 5 nM | [2] | |
| Action against Disease Model | Adapalene | Drug Info | Normal h uMan keratinocytes transglutaminase 1 expression IC50: 2.5 nM | [3] | |
| Isotretinoin | Drug Info | EC50 on differentiating N1E-115 cells: 16000nM | [1] | ||
| References | |||||
| REF 1 | Effect of culture age on the susceptibility of differentiating neuroblastoma cells to retinoid cytotoxicity. Biotechnol Bioeng. 1996 Jun 5;50(5):580-6. | ||||
| REF 2 | Didehydroretinoic acid: retinoid receptor-mediated transcriptional activation and binding properties. Biochem Pharmacol. 1997 Apr 4;53(7):1049-53. | ||||
| REF 3 | Pharmacology of adapalene. Br J Dermatol. 1998 Oct;139 Suppl 52:3-7. | ||||
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