| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T11843 | ||||
| Target Name | Vitamin K epoxide reductase complex 1 (VKORC1) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Dicumarol | Drug Info | Ki = 600 nM | [2] | |
| Phenprocoumon | Drug Info | ED50 = 100~300 uM | [1] | ||
| References | |||||
| REF 1 | Non-peptidic HIV protease inhibitors. Curr Top Med Chem. 2004;4(10):1097-114. | ||||
| REF 2 | Development and validation of an in silico P450 profiler based on pharmacophore models. Curr Drug Discov Technol. 2006 Mar;3(1):1-48. | ||||
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