Target Validation Information
TTD ID T12126
Target Name Mixed lineage kinase 3 (MAP3K11)
Type of Target
Literature-reported
Drug Potency against Target CEP-5104 Drug Info IC50 = 55 nM [1]
CEP-6331 Drug Info IC50 = 65 nM [1]
References
REF 1 Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9.

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