Target Validation Information
TTD ID	T13491
Target Name	Solute carrier family 29 member 1 (SLC29A1)
Type of Target	Successful
Drug Potency against Target	6-(4-Nitro-benzylsulfanyl)-9-phenethyl-9H-purine	Drug Info	Ki = 2200 nM	[1]
	9-Benzyl-6-(4-nitro-benzylsulfanyl)-9H-purine	Drug Info	Ki = 135 nM	[1]
	LIDOFLAZINE	Drug Info	Ki = 279.9 nM	[3]
	N6-CYCLOPENTYLADENOSINE	Drug Info	Ki = 1100 nM	[2]
	S6-nitrobenzyl mercaptopurine riboside	Drug Info	Ki = 0.7 nM	[4]
References
REF 1	Inhibition of nucleoside transport by new analogues of 4-nitrobenzylthioinosine: replacement of the ribose moiety by substituted benzyl groups. J Med Chem. 2004 Oct 21;47(22):5441-50.
REF 2	Inhibition of nucleoside transport proteins by C8-alkylamine-substituted purines. J Med Chem. 2005 Jan 13;48(1):321-9.
REF 3	Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibit... J Med Chem. 2007 Aug 9;50(16):3906-20.
REF 4	Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):917-21.

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