Target Validation Information
TTD ID T13795
Target Name Neuronal acetylcholine receptor alpha-9 (CHRNA9)
Type of Target
Literature-reported
Drug Potency against Target ACV-1 Drug Info IC50 = 19 nM
Action against Disease Model ACV-1 Drug Info Stable MDA-MB-231 breast cancer cell lines were established in which expression of the alpha9-nAChR subunit was inhibited using short interfering RNA. MCF-10A normal h uMan breast epithelial cells were established in which the alpha9-nAChR subunit could be conditionally overexpressed by removal of doxycycline from the culture fluid. Cell proliferation and soft agar assays and t uMor growth in nude mice were used as measures of cell transformation. All statistical tests were two-sided. [1]
References
REF 1 Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells. J Natl Cancer Inst. 2010 Sep 8;102(17):1322-35.

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