Target Validation Information
TTD ID T16156
Target Name Thrombopoietin receptor (MPL)
Type of Target
Successful
Drug Potency against Target Drug Info pKi = 7.76 [1]
Totrombopag Drug Info IC50 = 170 nM [2]
References
REF 1 Agonists and antagonists targeting the different alpha2-adrenoceptor subtypes. Curr Top Med Chem. 2007;7(2):163-86.
REF 2 Recent advances in the development of multi-kinase inhibitors. Mini Rev Med Chem. 2008 Nov;8(13):1312-27.

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