Target Validation Information
TTD ID	T17140
Target Name	P2X purinoceptor 3 (P2RX3)
Type of Target	Clinical trial
Drug Potency against Target	AVVYPWT	Drug Info	IC50 = 14.3 nM	[2]
	Cyclic LVVYPWT	Drug Info	IC50 = 82.4 nM	[2]
	ISOPPADS	Drug Info	IC50 = 74 nM	[1]
	LAVYPWT	Drug Info	IC50 = 32.4 nM	[2]
References
REF 1	Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. J Med Chem. 2001 Feb 1;44(3):340-9.
REF 2	Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7.

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